The state of psychological services for people with physical and cognitive disabilities: an integrative systematic review

The present study investigated the state of psychotherapy for people with physical and cognitive disabilities in a systematic review. Specifically, this study analyzed qualitative and quantitative studies which examined therapists’ abilities to conceptualize disability as a dimension of cultural competence, the models and conceptualizations of disability and psychotherapy being used with people with disabilities (PWD) in psychotherapy, and the experiences of PWD in psychotherapy. This study analyzed 18 empirical studies and integrated both qualitative and quantitative methods. Source eligibility criteria for this systematic review was the same for both qualitative and quantitative studies. Eligibility criteria included being: peer-reviewed journal articles, international and domestic locations, in the English Language, and published after 2010. This review excluded case studies. The researchers appraised the quality of each study using the Critical Appraisal Form, and recorded the research variables from each study using the Data Collection and Extraction Form. Data was then entered into customized Excel spreadsheets in the form of Evidence Tables. A synthesis of important findings was conducted to describe the similar themes found in the data. The findings of this research point to the need for further research which includes PWD in psychotherapy, such as improving therapists’ cultural competence, more variety of psychotherapy orientations and models for PWD, and increased narratives of PWD in psychotherapy

Convocation

Program listing performers and works performe

Scoping potential routes to UK civil unrest via the food system: Results of a structured expert elicitation

We report the results of a structured expert elicitation to identify the most likely typesof potential food system disruption scenarios for the UK, focusing on routes to civil unrest. Wetake a backcasting approach by defining as an end-point a societal event in which 1 in 2000 peoplehave been injured in the UK, which 40% of experts rated as “Possible (20–50%)”, “More likely thannot (50–80%)” or “Very likely (>80%)” over the coming decade. Over a timeframe of 50 years, thisincreased to 80% of experts. The experts considered two food system scenarios and ranked theirplausibility of contributing to the given societal scenario. For a timescale of 10 years, the majorityidentified a food distribution problem as the most likely. Over a timescale of 50 years, the expertswere more evenly split between the two scenarios, but over half thought the most likely route tocivil unrest would be a lack of total food in the UK. However, the experts stressed that the variouscauses of food system disruption are interconnected and can create cascading risks, highlighting theimportance of a systems approach. We encourage food system stakeholders to use these results intheir risk planning and recommend future work to support prevention, preparedness, response andrecovery planning

Resolvins suppress tumor growth and enhance cancer therapy

National Cancer Institute grants RO1 01CA170549-02 (to D. Panigrahy and C.N. Serhan), ROCA148633-01A4 (to D. Panigrahy), and GM095467 (to C.N. Serhan); the Stop and Shop Pediatric Brain Tumor Fund (to M.W. Kieran); the CJ Buckley Pediatric Brain Tumor Fund (to M.W. Kieran); Alex Lemonade Stand (to M.W. Kieran); Molly’s Magic Wand for Pediatric Brain Tumors (to M.W. Kieran); the Markoff Foundation Art-In-Giving Foundation (to M.W. Kieran); the Kamen Foundation (to M.W. Kieran); Jared Branfman Sunflowers for Life (to M.W.K.); and The Wellcome Trust program 086867/Z/08 (to M. Perretti)

Target cell availability, rather than breast milk factors, dictates mother-to-infant transmission of SIV in sooty mangabeys and rhesus macaques.

Mother-to-infant transmission (MTIT) of HIV is a serious global health concern, with over 300,000 children newly infected in 2011. SIV infection of rhesus macaques (RMs) results in similar rates of MTIT to that of HIV in humans. In contrast, SIV infection of sooty mangabeys (SMs) rarely results in MTIT. The mechanisms underlying protection from MTIT in SMs are unknown. In this study we tested the hypotheses that breast milk factors and/or target cell availability dictate the rate of MTIT in RMs (transmitters) and SMs (non-transmitters). We measured viral loads (cell-free and cell-associated), levels of immune mediators, and the ability to inhibit SIV infection in vitro in milk obtained from lactating RMs and SMs. In addition, we assessed the levels of target cells (CD4+CCR5+ T cells) in gastrointestinal and lymphoid tissues, including those relevant to breastfeeding transmission, as well as peripheral blood from uninfected RM and SM infants. We found that frequently-transmitting RMs did not have higher levels of cell-free or cell-associated viral loads in milk compared to rarely-transmitting SMs. Milk from both RMs and SMs moderately inhibited in vitro SIV infection, and presence of the examined immune mediators in these two species did not readily explain the differential rates of transmission. Importantly, we found that the percentage of CD4+CCR5+ T cells was significantly lower in all tissues in infant SMs as compared to infant RMs despite robust levels of CD4+ T cell proliferation in both species. The difference between the frequently-transmitting RMs and rarely-transmitting SMs was most pronounced in CD4+ memory T cells in the spleen, jejunum, and colon as well as in central and effector memory CD4+ T cells in the peripheral blood. We propose that limited availability of SIV target cells in infant SMs represents a key evolutionary adaptation to reduce the risk of MTIT in SIV-infected SMs

Clinical features of nonhuman primate infants.

<p>Clinical features of nonhuman primate infants.</p

Similar cell-free and cell-associated SIV levels in blood and milk from RMs and SMs following pharmacologic induction of lactation.

<p>Lactation was induced using intramuscular injections of estradiol and medroxyprogesterone along with oral haloperidol followed by oxytocin injections to stimulate the milk ejection reflex. Over the 20 weeks of this study, plasma viral loads were measured via SIV RNA real time RT-PCR every 2 weeks (A). Breast milk was collected from RMs and SMs and cell-free SIV RNA was quantified in the de-fatted milk fraction by RT-PCR (B). Cell-associated SIV DNA was then measured in both PBMCs (C) and breast milk cells (D) with simultaneous albumin detection to determine cell number per reaction. Dashed lines represented the lower limit of detection for the assay. Undetectable values were plotted as half the lower limit of detection. Area under the curve analyses followed by nonparametric Mann-Whitney test was used to assess significance.</p

Clinical characteristics of chronically SIV-infected, female nonhuman primates.

<p>Clinical characteristics of chronically SIV-infected, female nonhuman primates.</p

Memory and effector CD4+ and CD8+ T cell subsets in SM milk.

<p>The cellular fraction of breast milk was stained with monoclonal antibodies to identify the relative proportions of T cell subsets. Gating strategy was as follows: CD45 vs CD3 to identify hematopoietic T cells, then CD20 vs CD14 to exclude B cells and monocytes/macrophages, respectively, then CD4 vs CD8. The CD4+ and CD8+ populations were stained with CD28 and CD95 to identify naïve (CD28+CD95−) and memory (CD28+/−CD95+) subsets. The memory population was further differentiated into effector (CCR7−) and central (CCR7+) memory subsets.</p